Older, archived, paediatric news
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December 2019
- In use product safety assessment report for Alkindi (hydrocortisone) granules in capsules for opening
- Paediatric Intensive Care Audit Network: Annual Report 2019
- NICE Bites – Fever in under 5s
- European Paediatric Formulary of extemporaneous preparations goes live
- December BNF/BNFC Newsletter.
- Fenfluramine hydrochloride for the treatment of seizures in Dravet syndrome: a randomised, double-blind, placebo-controlled trial
- Cannabidiol with clobazam for treating seizures associated with Lennox–Gastaut syndrome – guidance (TA615)
- Cannabidiol with clobazam for treating seizures associated with Dravet syndrome – guidance (TA614)
- Domperidone for nausea and vomiting: lack of efficacy in children; reminder of contraindications in adults and adolescents
- Approval of licence extension for cystic fibrosis therapy ivacaftor (Kalydeco)
- Irbesartan in Marfan syndrome (AIMS): a double-blind, placebo-controlled randomised trial
- Association Between Fertility Treatment and Cancer Risk in Children
- Summary of American Academy of Neurology guideline for acute treatment of migraine in children and adolescents and pharmacologic treatment for paediatric migraine prevention
- Does general anaesthesia affect neurodevelopment in infants and children?
- Revised SPC: Diovan 3 mg/ml Oral Solution (valsartan) – licensed for ages 1 to 6
- Clinical Commissioning Policy: Maternal intravenous immunoglobulin (IVIg) for the prevention of allo-immune fetal and neonatal haemochromatosis
- HPV: WHO calls for countries to suspend vaccination of boys
- National measles guidelines
November 2019
- General Pharmaceutical Council launches new guidance for pharmacist prescribers to ensure safe and effective prescribing
- Supply Disruption Alert: Emerade 150 microgram, 300 microgram and 500 microgram adrenaline auto-injector devices
- FDA approves Toujeo (insulin glargine) to treat childhood type 1 diabetes
- Educational Risk Minimisation Materials to help reduce the risk associated with using glycopyrronium bromide (Sialanar) 320 micrograms /ml Oral Solution
- November BNF/BNFC Newsletter
- Longitudinal, strain-specific Staphylococcus aureus introduction and transmission events in households of children with community-associated meticillin-resistant S aureus skin and soft tissue infection: a prospective cohort study
- Pre-school vaccinations: guide to vaccinations from 2 to 5 years
- Revised SPC: Qvar (beclometasone dipropionate) MDI – all strengths – pescribing information for 5 years and above
- Association of maternal antiretroviral use with microcephaly in children who are HIV-exposed but uninfected (SMARTT): a prospective cohort study
- Intravenous Ondansetron in Pregnancy and Risk of Congenital Malformations
- School-based interventions to prevent anxiety and depression in children and young people: a systematic review and network meta-analysis
- Practical aspects of childhood epilepsy
- Flu-vaccine nasal spray delayed for some schoolchildren
- Cannabidiol for adjuvant treatment of seizures associated with Lennox-Gastaut syndrome – Final Appraisal Determination
- Urgent Policy Statement: Cystic Fibrosis Modulator Therapies
- Efficacy of a Tetravalent Dengue Vaccine in Healthy Children and Adolescents
- Sanofi presents data from EDITION JUNIOR phase III trial of Toujeo (insulin glargine 300 Units/mL) vs. insulin glargine 100 Units/mL (Gla-100) in children and adolescents aged 6 to 17 years with type 1 diabetes
- NIHR Signals: Antimicrobial central venous catheters do not reduce infections in pre-term babies
- Fever in under 5s: assessment and initial management- guidance (NG143)
- Paediatric critical care and surgery in children review: Summary report
- Human and animal bites: antimicrobial prescribing – Draft guidance consultation
- Effect of Caspofungin vs Fluconazole Prophylaxis on Invasive Fungal Disease Among Children and Young Adults With Acute Myeloid Leukemia: A Randomized Clinical Trial
- Immunisations: babies up to 13 months of age
- FDA statement on new testing results, including low levels of impurities in ranitidine drugs
- Narsoplimab receives Positive Opinion from European Medicines Agency for Pediatric Investigation Plan required for licensing application
- Association of Cord Plasma Biomarkers of In Utero Acetaminophen Exposure With Risk of Attention-Deficit/Hyperactivity Disorder and Autism Spectrum Disorder in Childhood
- Zanamivir (Dectova®)
- Belimumab licence extension for use in children from age 5 approved in the European Union
- BNF/BNFC newsletter October 2019
October 2019
- Investigation into pre-school vaccinations routinely provided in England in 2018/2019
- FDA approves license extension for Botulinum A toxin for treatment of lower limb spasticity in children and adolescents aged 2 to 17 years
- Perinatal Management of Extreme Preterm Birth before 27 weeks of gestation: A Framework for Practice
- Effect of Fluoxetine on Obsessive-Compulsive Behaviors in Children and Adolescents With Autism Spectrum Disorders: A Randomized Clinical Trial
- Incidence of anorexia nervosa in young people in the UK and Ireland: a national surveillance study
- Committee for Medicinal Products for Human Use (CHMP) recommends approval of Baqsimi (glucagon)
- Chemotherapy and Risk of Subsequent Malignant Neoplasms in the Childhood Cancer Survivor Study Cohort
- Letter to healthcare professionals regarding parenteral nutrition products for neonates and children below 2 years of age – protect from light
- Adrenaline auto-injectors: recent actions taken to support safety
- Differences in lung function between children with sickle cell anaemia from West Africa and Europe
- Duration of intravenous antibiotic therapy in people with cystic fibrosis
- NICE draft Quality Standard published for consultation: Specialist neonatal respiratory care for babies born preterm
- Band ligation versus beta‐blockers for primary prophylaxis of oesophageal variceal bleeding in children with chronic liver disease or portal vein thrombosis
- Mandatory childhood vaccination could cause “irreparable damage,” says expert panel
- Oral non‐steroidal anti‐inflammatory drug therapy for lung disease in cystic fibrosis
- Patient-reported quality of life after tisagenlecleucel infusion in children and young adults with relapsed or refractory B-cell acute lymphoblastic leukaemia: a global, single-arm, phase 2 trial
- Once‐daily versus multiple‐daily dosing with intravenous aminoglycosides for cystic fibrosis
- Gastro-oesophageal reflux disease in children and young people: diagnosis and management – updated guidance (NG1)
- Fetal Alcohol Spectrum Disorder (FASD)
- New product: Epidyolex (cannabidiol) 100 mg/ml oral solution
- FDA accepts for review two New Drug Applications (NDAs) for fidaxomicin to treat children aged six months up to 18 years with Clostridium difficile infections
- Epilepsies: diagnosis and management- updated clinical guideline (CG137)
September 2019
- September 2019 BNF/BNFc newsletter
- US FDA approves Rituxan (rituximab) injection to treat granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA) in children 2 years of age and older in combination with glucocorticoids
- Pfizer announces positive results for abrocitinib in atopic dermatitis for patients 12 and older
- Montelukast (Singulair): reminder of the risk of neuropsychiatric reactions
- Fingolimod (Gilenya▼): increased risk of congenital malformations; new contraindication during pregnancy and in women of childbearing potential not using effective contraception
- Ipsen announces FDA approval of Dysport (abobotulinumtoxinA) for treatment of upper limb spasticity in children, excluding cerebral palsy
- DTB Commentary: Do oral steroids improve hearing outcomes in children with otitis media with effusion?
- TNF‐α blockers for the treatment of Kawasaki disease in children
- Childhood Vaccination Coverage Statistics – England 2018-19
- Vinorelbine and continuous low-dose cyclophosphamide as maintenance chemotherapy in patients with high-risk rhabdomyosarcoma (RMS 2005): a multicentre, open-label, randomised, phase 3 trial
- Immunoglobulin treatment for hospitalised infants and young children with respiratory syncytial virus infection
- European CHMP issues positive opinion for paediatric license extension of belimumab (Benlysta)
- Effect of measles vaccination in infants younger than 9 months on the immune response to subsequent measles vaccine doses: a systematic review and meta-analysis
- Pneumonia (hospital-acquired): antimicrobial prescribing- guideline [NG139]
- Sulthiame add‐on therapy for epilepsy
- Attention deficit hyperactivity disorder: diagnosis and management – updated guidance (NG87)
- UK immunisation schedule: the green book, chapter 11 updated
- FDA approves hydroxyprogesterone caproate (HPC) to prevent preterm birth
- Ranibizumab versus laser therapy for the treatment of very low birthweight infants with retinopathy of prematurity (RAINBOW): an open-label randomised controlled trial
- Methylphenidate and stuttering
- Neonatal parenteral nutrition – draft guidance
- Temporal Trends and Contemporary Use of Insulin Pump Therapy and Glucose Monitoring Among Children, Adolescents, and Adults With Type 1 Diabetes Between 1995 and 2017
- Use of tumour necrosis factor-α inhibitors and the risk of serious infection in paediatric inflammatory bowel disease in Denmark: a nationwide cohort study
- Twin and triplet pregnancy – guidance (NG137)
- NHS warning to parents as ‘asthma season’ hits
- August BNF/BNFC eNewsletter
- Vancomycin is commonly under‐dosed in critically ill children and neonates
- Revised SPCs: Strensiq (asfotase alfa) solution for injection (all strengths)
August 2019
- WHO revision of pain management guidelines
- Four European nations lose measles eradication status
- HbA1c level as a risk factor for retinopathy and nephropathy in children and adults with type 1 diabetes: Swedish population based cohort study
- MMR vaccine for 10 to 11 year old children: information for GPs
- Cannabidiol for adjuvant treatment of seizures associated with Dravet syndrome – Appraisal Consultation document
- Cannabidiol for adjuvant treatment of seizures associated with Lennox-Gastaut syndrome – appraisal consultation document
- European Commission grants extension of indication for Fiasp (insulin aspart) for use in children
- Emicizumab as prophylaxis in people with severe congenital haemophilia A without factor VIII inhibitors (all ages)
- Estimated 1 in 7 five years olds are not immunised against MMR
- NHS England to look at offering childhood vaccinations in healthcare settings other than general practice to increase childhood vaccine coverage
- Revised SPC: Dupixent (dupilumab) 300 mg solution for injection in pre-filled syringe – new paediatric indication
- Efficacy of oral amoxicillin–clavulanate or azithromycin for non-severe respiratory exacerbations in children with bronchiectasis (BEST-1): a multicentre, three-arm, double-blind, randomised placebo-controlled trial
- Intravenous ceftriaxone at home versus intravenous flucloxacillin in hospital for children with cellulitis: a cost-effectiveness analysis
- Association of Gluten Intake During the First 5 Years of Life With Incidence of Celiac Disease Autoimmunity and Celiac Disease Among Children at Increased Risk
- Antibiotic exposure and ‘response failure’ for subsequent respiratory tract infections: an observational cohort study of UK preschool children in primary care
- Inhaled corticosteroids for cystic fibrosis
- Buffered solutions versus 0.9% saline for resuscitation in critically ill adults and children
- New products: Amglidia (glibenclamide) 0.6 mg/mL and 6 mg/mL, oral suspension
- How and why porcine gelatine is used in vaccines for immunisation programmes
- A quick reference guide to Flu vaccines for children for winter 2019 to 2020
- Long-term risk of infections after treatment of childhood leukemia: a population-based cohort study using administrative health data
- Interventions for preventing obesity in children
- What were the impacts of the Committee on Safety of Medicines warning and publication of the NICE guidelines on trends in child and adolescent antidepressant prescribing in primary care? A population based study
- Manufacturers report positive results for dupilumab for severe atopic dermatitis in children aged 6-11 years
- Antibiotic therapy for chronic infection with Burkholderia cepacia complex in people with cystic fibrosis
- Respiratory syncytial virus (RSV): a scourge from infancy to old age
- Unmasking the vulnerabilities of uninfected children exposed to HIV
- Inhaled corticosteroids in children with persistent asthma: effects of different drugs and delivery devices on growth
- Probiotics for preventing acute otitis media in children
- Enzyme replacement therapy with laronidase (Aldurazyme) for treating mucopolysaccharidosis type I
- Educational Risk Minimisation Materials to help reduce the risk associated with the use of glycopyrronium bromide 1 mg/5 ml oral solution
- Ibuprofen for the prevention of patent ductus arteriosus in preterm and/or low birth weight infants
- Preterm labour and birth – updated guideline (NG25)
- Lipid emulsions for parenterally fed term and late preterm infants
- Lipid emulsions for parenterally fed preterm infants
July 2019
- European CHMP issues positive opinion recommending approval of license extension for Lucentis (ranibizumab) for treatment of ROP in preterm infants
- British guideline on the management of asthma- update
- Nusinersen for treating spinal muscular atrophy-technology appraisal guidance (TA588)
- Young people among those set to benefit from “hole in the heart” closure as part of the NHS Long Term Plan
- Variabilities in Childhood Cardiovascular Risk Factors and Incident Diabetes in Adulthood: The Bogalusa Heart Study
- Associations of Blood Pressure and Cholesterol Levels During Young Adulthood With Later Cardiovascular Events
- NIHR Signal: Levetiracetam is a useful alternative to phenytoin in stopping prolonged epileptic seizures in children
- NIHR Signal Insights into the transfer between children’s and adults’ services for young people with selected long-term conditions
- Autumn 2019: Complete Routine Immunisation Schedule
- Revised SPCs: Numeta E emulsion for infusion (all strengths).
- Health outcomes of young children born to mothers who received 2009 pandemic H1N1 influenza vaccination during pregnancy: retrospective cohort study
- From September 2019, boys in school year 8 to be offered the free Human Papilloma Virus (HPV) vaccine
- Conference report: positive results reported for rivaroxaban in paediatric venous thromboembolism
- Vitamin D for secondary prevention of acute wheeze attacks in preschool and school-age children
- Nusinersen (Spinraza) access agreement extended for paediatric spinal muscular atrophy
- Behind the Headlines: Asthma attacks triple when children return to school in September
- Suspected neurological conditions: recognition and referral – guidance (NG127)
- Intravenous sildenafil fails to provide benefit for treatment of neonates with persistent pulmonary hypertension (PPHN)
- Pediatric Post–Cardiac Arrest Care: A Scientific Statement From the American Heart Association
- Evaluation and Management of the Child and Adult With Fontan Circulation: A Scientific Statement From the American Heart Association
- Phase 4 CrisADe CARE 1 study evaluating crisaborole ointment 2% in children aged 3 months to less than 24 months with mild to moderate atopic dermatitis meets primary safety endpoints
- Clofarabine can replace anthracyclines and etoposide in remission induction therapy for childhood acute myeloid leukemia: The AML08 Multicenter, Randomized Phase III Trial
- Medical interventions for the prevention of platinum‐induced hearing loss in children with cancer
- Enteral lactoferrin for the treatment of sepsis and necrotizing enterocolitis in neonates
June 2019
- Tackling childhood obesity: £1.5 million funding for local projects
- Depression in children and young people: identification and management – guidance (NG134)
- Efficacy and Safety of Fast-Acting Insulin Aspart Compared With Insulin Aspart, Both in Combination With Insulin Degludec, in Children and Adolescents With Type 1 Diabetes: The onset 7 Trial
- NIHR Signal: antimicrobial central venous catheters (CVCs) do not reduce infections in pre-term babies
- Pneumococcal conjugate vaccines for preventing acute otitis media in children
- Association Between Self-reported Prenatal Cannabis Use and Maternal, Perinatal, and Neonatal Outcomes
- US FDA approves liraglutide (Victoza) for type 2 diabetes in children aged over 10 years
- The evolving research agenda for paediatric tuberculosis (TB) infection
- NHS England seeks feedback from commissioners on childhood obesity strategy
- Methylphenidate and the risk of psychosis in adolescents and young adults: a population-based cohort study
- Updated guidelines on post-exposure prophylaxis for measles issued
- US FDA grants priority review to rituximab in combination with glucocorticoids for treatment of granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA) in children from age two years
- The association between maternal body mass index and child obesity: A systematic review and meta-analysis
- Adjusting the dose in paediatric care: dispersing four different aspirin tablets and taking a proportion
- fluticasone propionate/formoterol fumarate (Flutiform®) accepted for use within NHSScotland in children aged 5-12 years
- fingolimod (Gilenya®) accepted for use within NHSScotland in children aged 10-18 years
- Increasing influenza immunisation uptake among children – leaflet for general practice
- Inhaled hypertonic saline in preschool children with cystic fibrosis (SHIP): a multicentre, randomised, double-blind, placebo-controlled trial
- Childhood Asthma Management in Primary Care – Implementation of Exhaled Nitric Oxide and Spirometry Testing (CHAMPIONS study)
- Should measles vaccination be compulsory?
- Pivotal phase III ARTEMIS trial reports consistent safety and efficacy of AR101 in children and adolescents with peanut allergy
- Rotavirus vaccine (Rotarix®): patient group direction (PGD) template (updated)
- MenACWY vaccine (Menveo® or Nimenrix®): patient group direction (PGD) template (updated)
- Transition between child and adult services for young people with attention-deficit hyperactivity disorder (ADHD): findings from a British national surveillance study
- Clinical presentation, diagnosis, and management of fetal alcohol spectrum disorder
- Modernising vaccine surveillance systems to improve detection of rare or poorly defined adverse events
- Sixteen-week versus standard eight-week prednisolone therapy for childhood nephrotic syndrome: the PREDNOS RCT
May 2019
- May BNF/BNFC eNewsletter
- Prevalence of maternal mental illness among children and adolescents in the UK between 2005 and 2017: a national retrospective cohort analysis
- US FDA approves gene therapy onasemnogene abeparvovec-xioi to treat paediatric patients (less than 2 years of age) with spinal muscular atrophy (SMA)
- Maternal and fetal outcomes in pregnancies complicated by Marfan syndrome
- Interventions to improve the mental health of children and young people with long-term physical conditions: linked evidence syntheses
- Emerging challenges in pharmacotherapy research on attention-deficit hyperactivity disorder—outcome measures beyond symptom control and clinical trials
- Neurodevelopmental effects of ante-partum and post-partum antiretroviral exposure in HIV-exposed and uninfected children versus HIV-unexposed and uninfected children in Uganda and Malawi: a prospective cohort study
- Association of Changes in Air Quality With Incident Asthma in Children in California, 1993-2014
- Young Children Have Higher Variability of Insulin Requirements: Observations During Hybrid Closed-Loop Insulin Delivery
- Maximizing the Benefit of Life-Saving Treatments for Pompe Disease, Spinal Muscular Atrophy, and Duchenne Muscular Dystrophy Through Newborn Screening: Essential Steps
- US FDA approves nasal midazolam for acute repetitive seizures
- Fragmin (dalteparin sodium) approved by FDA as first anticoagulant for children
- Hepatic late adverse effects after antineoplastic treatment for childhood cancer
- Long‐term antibiotics for preventing recurrent urinary tract infection in children
- Probiotics for the prevention of paediatric antibiotic‐associated diarrhoea
- The changing burden of long-term health outcomes in survivors of childhood acute lymphoblastic leukaemia: a retrospective analysis of the St Jude Lifetime Cohort Study
- Association of Gestational Weight Gain With Adverse Maternal and Infant Outcomes
- New Product: Sprycel (dasatinib) 10 mg/mL powder for oral suspension
- Epanutin (phenytoin) 50mg Infatabs (Pfizer) supply issue
- Preterm birth and risk of chronic kidney disease from childhood into mid-adulthood: national cohort study
- US FDA approves amifampridine for children with Lambert-Eaton myasthenic syndrome
- Health Secretary considers ‘all options’ to boost vaccine uptake
- Revised SPC: Bramitob (tobramycin) Nebuliser Solution
- New Product: Sprycel (dasatinib) 10 mg/mL powder for oral suspension
- Interventions for infantile seborrhoeic dermatitis (including cradle cap)
- Conference abstract – RCT reports cannabidiol (CBD) reduces convulsive seizure frequency in children and adolescents with Dravet syndrome
April 2019
- 2019 American College of Rheumatology/Arthritis Foundation Guideline for the Screening, Monitoring, and Treatment of Juvenile Idiopathic Arthritis–Associated Uveitis
- Oral immunotherapy for peanut allergy (PACE): a systematic review and meta-analysis of efficacy and safety
- Early and late adverse renal effects after potentially nephrotoxic treatment for childhood cancer
- Liraglutide in Children and Adolescents with Type 2 Diabetes
- UNICEF reports over 20 million children worldwide missed out on measles vaccine annually in past 8 years creating a pathway to current global outbreaks
- BioMarin confirms all UK patients who took part in clinical trials of sapropterin dihydrochloride (Kuvan) for phenylketonuria (PKU) will be able to access drug after trials end
- Association of Exposure to Infections in Childhood With Risk of Eating Disorders in Adolescent Girls
- Revised SPCs: ORENCIA (abatacept) 50, 87.5 and 125mg solution for injection (pre-filled syringe)
- Revised SPC: Epistatus 10 mg Oromucosal Solution – Carer instructions for administration updated
- Brivaracetam add‐on therapy for drug‐resistant epilepsy
- Innovative child malaria vaccine to be tested in Malawi
- Maternal Glycemic Control in Type 1 Diabetes and the Risk for Preterm Birth: A Population-Based Cohort Study
- Hepatitis C virus infection in children and adolescents
- Hepatitis B virus infection in children and adolescents
- UK immunisation schedule: the green book, chapter 11 (updated)
- Probiotics to prevent infantile colic
- Valproate medicines and serious harms in pregnancy: new Annual Risk Acknowledgement Form and clinical guidance from professional bodies to support compliance with the Pregnancy Prevention Programme
- Levetiracetam versus phenytoin for second-line treatment of paediatric convulsive status epilepticus (EcLiPSE): a multicentre, open-label, randomised trial
- Levetiracetam versus phenytoin for second-line treatment of convulsive status epilepticus in children (ConSEPT): an open-label, multicentre, randomised controlled trial
- Rapid Over Infusion of Parenteral Nutrition (PN)- update to Patient Safety Alert NHS/PSA/W/2017/005 issued Sept 2017
- NHS staff and parents to gain access to crucial child health information
- Hepatitis virus infection in children and adolescents
- Intermittent Versus Continuous PEG-Asparaginase to Reduce Asparaginase-Associated Toxicities: A NOPHO ALL2008 Randomized Study
- Saving Babies’ Lives Version Two: A care bundle for reducing perinatal mortality
- Adalimumab in combination with methotrexate for refractory uveitis associated with juvenile idiopathic arthritis: a RCT
- Dasotraline in Children with Attention-Deficit/Hyperactivity Disorder: A Six-Week, Placebo-Controlled, Fixed-Dose Trial
- Maternal pertussis vaccination and its effects on the immune response of infants aged up to 12 months in the Netherlands: an open-label, parallel, randomised controlled trial
- Clinical and biological predictors of response to standardised paediatric colitis therapy (PROTECT): a multicentre inception cohort study
- Continuous subcutaneous insulin infusion versus multiple daily injection regimens in children and young people at diagnosis of type 1 diabetes: pragmatic randomised controlled trial and economic evaluation
- NIHR Signal: Does an antibacterial milk protein reduce infection in premature babies?
- Specialist neonatal respiratory care for babies born preterm (NG 124) – guidance
- New presentation: Fycompa (perampanel) 0.5 mg/ml oral suspension
- February BNF/BNFC eNewsletter
March 2019
- Transforming children’s services
- Association of Prenatal Cannabis Exposure With Psychosis Proneness Among Children in the Adolescent Brain Cognitive Development (ABCD) Study
- Antibiotic treatment for newborns with congenital syphilis
- Current and Future Challenges for Children Across the World
- NHS England Specialised Commissioning document: Selective Dorsal Rhizotomy for treatment of spasticity in cerebral palsy
- Chloramphenicol: is it safe in breastfeeding?
- Efficacy, immunogenicity and safety of a recombinant tetravalent dengue vaccine (CYD-TDV) in children aged 2–17 years: systematic review and meta-analysis
- High-Dose Vitamin D Supplementation During Pregnancy and Asthma in Offspring at the Age of 6 Years
- NHS and Vertex remain deadlocked over price of Orkambi (lumacaftor/ivacaftor)
- Efficacy of primary treatment with immunoglobulin plus ciclosporin for prevention of coronary artery abnormalities in patients with Kawasaki disease predicted to be at increased risk of non-response to intravenous immunoglobulin (KAICA)
- Efficacy and safety of intravenous ceftriaxone at home versus intravenous flucloxacillin in hospital for children with cellulitis (CHOICE): a single-centre, open-label, randomised, controlled, non-inferiority trial
- Association of Atopic Dermatitis With Sleep Quality in Children
- First 1000 days of life
- A priori choice of neuraxial labour analgesia and breastfeeding initiation success: a community-based cohort study in an Italian baby-friendly hospital
- What is the sodium content of medicines?
- First-Line Treatment of Patients With Indolent Non-Hodgkin Lymphoma or Mantle-Cell Lymphoma With Bendamustine Plus Rituximab Versus R-CHOP or R-CVP: Results of the BRIGHT 5-Year Follow-Up Study
- Outcomes of patients with childhood B-cell precursor acute lymphoblastic leukaemia with late bone marrow relapses: long-term follow-up of the ALLR3 open-label randomised trial
- Postoperative epidural analgesia versus systemic analgesia for thoraco‐lumbar spine surgery in children
- Measles, Mumps, Rubella Vaccination and Autism: A Nationwide Cohort Study
- Theophylline and aminophylline for prevention of acute kidney injury in neonates and children: a systematic review
- Biologics for paediatric severe asthma: trick or TREAT?
- School‐based self‐management interventions for asthma in children and adolescents: a mixed methods systematic review
February 2019
- Cardiovascular Risk Reduction in High-Risk Pediatric Patients: A Scientific Statement From the American Heart Association
- Pertussis (whooping cough)
- Effect of Epicutaneous Immunotherapy vs Placebo on Reaction to Peanut Protein Ingestion Among Children With Peanut Allergy: The PEPITES Randomized Clinical Trial
- Universal antenatal screening for group B streptococcus may cause more harm than good
- Topiramate for juvenile myoclonic epilepsy
- Neurodevelopmental outcome at 5 years of age after general anaesthesia or awake-regional anaesthesia in infancy (GAS): an international, multicentre, randomised, controlled equivalence trial
- Spina bifida: information for parents
- Althea to launch cannabis based products in the UK
- Eisai submits application to extend licence of perampanel to include treatment of paediatric patients with epilepsy
- Enterovirus as trigger of coeliac disease: nested case-control study within prospective birth cohort
- Association of Cannabis Use in Adolescence and Risk of Depression, Anxiety, and Suicidality in Young Adulthood: A Systematic Review and Meta-analysis
- Child abuse and neglect- quality standard (QS179)
- Cases of measles in Europe at highest rate in a decade due to growing number of areas where parents are refusing vaccination for their children
- European Commission approves dasatinib in combination with chemotherapy for treatment of paediatric patients with newly diagnosed Philadelphia chromosome-positive acute lymphoblastic leukaemia
- Adoption of Peristeen at Alder Hey Children’s Hospital
- New product: OZALIN (midazolam) 2 mg/ml oral solution in single-dose container
- Education Secretary announces that up to 370 schools in England will take part in a series of trials testing different approaches to supporting young people’s mental health
- January 2019 BNF/ BNF C eNewsletter
- Childhood obesity: time for action report – government response
- European CHMP recommends license extension of abatacept (Orencia) for treatment of olyarticular juvenile idiopathic arthritis
- European CHMP recommends atazanavir (Atazanavir Krka) for treatment of HIV-1 in adults and children 6 years of age and older
- Mental health trial launches in schools in England
January 2019
- Limited evidence for non-drug treatment of childhood ADHD: DTB Select summary
- Seizures and quinolone antibiotics in children: a systematic review of adverse events
- Early access to medicines scheme (EAMS) scientific opinion: Dupilumab as a treatment of adolescent patients between 12 and 18 years of age with severe atopic dermatitis for whom the available systemic therapies are not suitable
- Depression in children and young people: identification and management – DRAFT guidance
- Children and young people exposed prenatally to alcohol
- Determining the reasons for poorly controlled asthma in an adolescent
- European Commission approves paediatric license extension of Orkambi (lumacaftor/ivacaftor) for cystic fibrosis
- Mental health services for children and young people
- PCV (13-valent, adsorbed): patient group direction (PGD) template
- Flutiform (fluticasone/ formoterol) approved in EU for treatment of children with asthma aged five years and over
- Tiotropium (Spiriva® Respimat®) for asthma in paediatric patients
- Sedation of children undergoing dental treatment
- Recombinant growth hormone therapy for cystic fibrosis in children and young adults
- Maternal probiotic supplementation for prevention of morbidity and mortality in preterm infants
- Enteral lactoferrin supplementation for very preterm infants: a randomised placebo-controlled trial
- Childhood cancer burden: a review of global estimates
- Revised SPC: Ravicti (glycerol phenylbutyrate) 1.1 g/ml oral liquid
- Everolimus for refractory focal onset seizures associated with tuberous sclerosis complex (ages 2 years and above): Clinical Commissioning Policy
December 2018
- Paediatric extrapolation: A necessary paradigm shift
- Which medicines require extra care when switching between liquid and tablet/capsule formulations?
- BNF/BNFC eNewsletter December 2018
- Notification of the discontinuation of Zovirax (aciclovir) eye ointment 3% 4.5g
- Antibiotic and acid-suppression medications during early childhood are associated with obesity
- Hydrocortisone muco-adhesive buccal tablets: should not be used off-label for adrenal insufficiency in children due to serious risks
- Single, short-time exposure to heat in a car during sunny day can decrease epinephrine concentration in autoinjectors: a real-life pilot study
- Ketogenic diets for drug‐resistant epilepsy
- Oral lidocaine-containing products for infant teething: only to be available under the supervision of a pharmacist
- Timing of dornase alfa inhalation for cystic fibrosis
- Protocol‐directed sedation versus non‐protocol‐directed sedation in mechanically ventilated intensive care adults and children
- Melatonin in children with cancer
- Maternal immunisation to improve the health of HIV-exposed infants
- Evaluation of the safety of live attenuated influenza vaccine (LAIV) in children and adolescents with asthma and high-risk conditions: a population-based prospective cohort study conducted in England with the Clinical Practice Research Datalink
November 2018
- Ivacaftor approved in the EU to treat patients aged 12 to ≤24 months with certain mutations in the CFTR gene
- Early intervention for depression in young people: a blind spot in mental health care
- Manufacturers report positive outcomes for triple combination therapy in cystic fibrosis in preliminary data from phase III trials
- Children’s Commissioner for England publishes new analysis on the provision of children’s mental health services in England
- Multicenter Trial of a Combination Probiotic for Children with Gastroenteritis
- Lactobacillus rhamnosus GG versus Placebo for Acute Gastroenteritis in Children
- Help make medicines safer: report suspected side effects in children and during pregnancy
- European CHMP recommends approval of two paediatric formulations of lumacaftor / ivacaftor (Orkambi)
- AR101 Oral Immunotherapy for Peanut Allergy
- European CHMP endorses suspension or restrictions of quinolone and fluoroquinolone antibiotics due to disabling and potentially permanent adverse effects
- Childhood Immunisation CCG/GP Practice level coverage statistics 2017-18 (Management Information)
- European Medicines Agency issues guidance on safety monitoring of medicines used in children
- NIHR Signal: Oral steroids do not help hearing for children with glue ear
- Sildenafil (Revatio and Viagra): reports of persistent pulmonary hypertension of the newborn (PPHN) following in-utero exposure in a clinical trial on intrauterine growth restriction
- Cannabis-based products for medicinal use: Guideline scope
- Heliox for croup in children
- Supporting public health: children, young people and families
- Temporal patterns in the risk of chronic health conditions in survivors of childhood cancer diagnosed 1970–99: a report from the Childhood Cancer Survivor Study cohort
- Oral steroids for hearing loss associated with otitis media with effusion in children aged 2 8 years: the OSTRICH RCT
- Inhaled antibiotics for pulmonary exacerbations in cystic fibrosis
- New product: Symkevi (100mg tezacaftor/ 150mg ivacaftor) film coated tablets
- Cannabis based drugs: how will they be used in practice?
- European Commission approves Symveki (tezacaftor/ivacaftor) for treatment of selected patients with cystic fibrosis
- Chief medical officer (CMO) urges parents to get children vaccinated and ignore “social media fake news” about MMR vaccine
- Pharmacological and non-pharmacological interventions for non-respiratory sleep disturbance in children with neurodisabilities: a systematic review
- Cannabis-based products for medicinal use: Guidance to clinicians
- The supply, manufacture, importation and distribution of unlicensed cannabis-based products for medicinal use in humans ‘specials’
- Nebulised hypertonic saline for cystic fibrosis
- Ibuprofen for the treatment of patent ductus arteriosus in preterm or low birth weight (or both) infants
October 2018
- Pregnancy problems: a guide for pharmacy
- US FDA approves sodium oxybate (Xyrem®) oral solution for treatment of cataplexy or excessive daytime sleepiness in paediatric narcolepsy patients
- GPhC statement on supplying valproate safely to women and girls
- Royal Pharmaceutical Society (RPS) practical guide to support pharmacist independent prescribers
- Maternal paracetamol intake and fetal ductus arteriosus constriction or closure: a case series analysis
- Effect of childhood pneumococcal conjugate vaccination on invasive disease in older adults of 10 European countries: implications for adult vaccination
- Adding emollient bath additives to standard eczema management for children with eczema: the BATHE RCT
- October 2018 BNF/BNFC eNewsletter
- Corticosteroids for preventing neonatal respiratory morbidity after elective caesarean section at term
- European CHMP recommends approval of extension to existing indication of ivacaftor (Kalydeco)
- VX-659–Tezacaftor–Ivacaftor in Patients with Cystic Fibrosis and One or Two Phe508del Alleles
- VX-445–Tezacaftor–Ivacaftor in Patients with Cystic Fibrosis and One or Two Phe508del Alleles
- Vitamin A and beta (β)‐carotene supplementation for cystic fibrosis
- Maternal Antibiotic Use During Pregnancy and Type 1 Diabetes in Children: A National Prospective Cohort Study
- Assessment and initial management of suspected behavioural insomnia in pre-adolescent children
- β-Blocker Use in Pregnancy and the Risk for Congenital Malformations: An International Cohort Study
- Tuberculosis susceptibility and protection in children
- Strategies to improve detection and management of human parechovirus infection in young infants
- NHS England – Junior Epipen shortage
- Revised SPC: Isentress (raltegravir) 100 mg Granules for Oral Suspension – extension to neonates
- Specialist neonatal respiratory care for babies born preterm
- Needle size for vaccination procedures in children and adolescents
- Glucocorticoids for croup in children
- Improving children and young people’s mental health services
- Transdermal fentanyl patches: life-threatening and fatal opioid toxicity from accidental exposure, particularly in children
- Improving children and young people’s mental health services
- Does melatonin improve sleep in children with neurodevelopmental disorders?
- Lipid‐based nutrient supplements for maternal, birth, and infant developmental outcomes
- Burosumab for treating X-linked hypophosphataemia in children and young people – guidance (HST8)
- Coeliac disease in children
- Different infusion durations for preventing platinum‐induced hearing loss in children with cancer
September 2018
- Boosting the development of medicines for children
- Poor Metabolic Control in Children and Adolescents With Type 1 Diabetes and Psychiatric Comorbidity
- Positive Phase II data for once-weekly growth hormone analogue (somapacitan) in childhood growth hormone deficiency
- Meningitis report: Spotting a seriously ill child
- Ketorolac for postoperative pain in children
- September BNF/BNFC eNewsletter
- Medical and surgical interventions for the treatment of urinary stones in children
- Amoxicillin–clavulanate versus azithromycin for respiratory exacerbations in children with bronchiectasis (BEST-2): a multicentre, double-blind, non-inferiority, randomised controlled trial
- Long-Term Risk of Venous Thromboembolism in Survivors of Childhood Cancer: A Report From the Childhood Cancer Survivor Study
- Long-term developmental effects of withholding parenteral nutrition for 1 week in the paediatric intensive care unit: a 2-year follow-up of the PEPaNIC international, randomised, controlled trial
- Long-Term Risk of Venous Thromboembolism in Survivors of Childhood Cancer: A Report From the Childhood Cancer Survivor Study
- Pharmacological treatment for attention deficit hyperactivity disorder (ADHD) in children with comorbid tic disorders
- Impact of antibiotics for children presenting to general practice with cough on adverse outcomes: secondary analysis from a multicentre prospective cohort study
- Methylphenidate for attention deficit hyperactivity disorder (ADHD) in children and adolescents – assessment of adverse events in non‐randomised studies
- Bronchiectasis in children: diagnosis and treatment
- Tisagenlecleucel to be made available on NHS for children and adults up to age 25 years for B cell acute lymphoblastic leukaemia
- Burosumab for treating X-linked hypophosphataemia in children and young people – Final appraisal determination
- The Good Childhood Report 2018
- Treatment of extravasation injuries in infants and young children: a scoping review and survey
- An overview of the EU’s orphan designation programme
- Face‐to‐face interventions for informing or educating parents about early childhood vaccination
- Clonazepam add‐on therapy for refractory epilepsy in adults and children
- Revised SPC: Blincyto (blinatumomab) solution
August 2018
- Mepolizumab approved in EU for treatment of paediatric patients with severe eosinophilic asthma
- Paracetamol (acetaminophen) for patent ductus arteriosus (a blood vessel necessary for fetal survival) in preterm and low birth weight infants
- Interventions for infantile haemangiomas of the skin
- Honey for acute cough in children
- BNF and BNF for Children Update: August 2018
- Local anaesthetics and regional anaesthesia versus conventional analgesia for preventing persistent postoperative pain in adults and children
- National Paediatric Diabetes Audit
- Perinatal Marijuana Use and the Developing Child
- Paediatric intensive care and neonatal intensive care airway management in the United Kingdom: the PIC‐NIC survey
- Video on valproate use during pregnancy to support healthcare professionals
- The Risk of Offspring Psychiatric Disorders in the Setting of Maternal Obesity and Diabetes
- Type 1 Diabetes in Children and Adolescents: A Position Statement by the American Diabetes Association
- Changing geographical patterns and trends in cancer incidence in children and adolescents in Europe, 1991–2010 (Automated Childhood Cancer Information System): a population-based study
- Vitamin D Supplementation in Pregnancy and Lactation and Infant Growth
- FDA approve lumacaftor/ivacaftor (Orkambi) Cystic Fibrosis for Children Ages 2-5 Years in US
- Benzodiazepine prescribing for children, adolescents, and young adults from 2006 through 2013: A total population register-linkage study
- Effect of a Responsive Parenting Educational Intervention on Childhood Weight Outcomes at 3 Years of Age: The INSIGHT Randomized Clinical Trial
- NIHR Signal Adding emollients to the bath unlikely to help children with eczema
- Comparative efficacy and tolerability of medications for attention-deficit hyperactivity disorder in children, adolescents, and adults: a systematic review and network meta-analysis
- Revised SPC: Rotarix (Human rotavirus, RIX4414 strain, live, attenuated) Oral Applicator
- Revised SPC: Briviact (brivaracetam) 10 mg/ml oral solution – licensed from 4 years of age
- Safety and Side Effects of Rifampin versus Isoniazid in Children
July 2018
- Association Between the New York Sepsis Care Mandate and In-Hospital Mortality for Pediatric Sepsis
- BNF and BNFC Update: July 2018
- Revised SPC: Gentamicin Intrathecal 5mg/ml – no longer contra-indicated in under one year of age
- Clarification of the doses at extremes of body-weight statement for vancomycin in BNF and BNF for Children
- Antidepressant prescriptions for children on the rise
- In use product safety assessment report for intravenous paracetamol in paediatrics
- Scientific Advisory Committee on Nutrition (SACN) publishes report on ‘Feeding in the first year of life’
- Perinatal Marijuana Use and the Developing Child
- Recurrent lower respiratory tract infections in children
- Periconception glycaemic control in women with type 1 diabetes and risk of major birth defects: population based cohort study in Sweden
June 2018
- NIHR Signal: Oral ibuprofen may be an option for closing patent ductus arteriosus in premature babies
- Xenidate XL (methylphenidate) Prolonged-release Tablets: Checklist before prescribing
- MHRA will continue to monitor safety of opioid patches after baby’s death
- European CHMP recommends approval of tisagenlecleucel (Kymriah) for acute lymphoblastic leukaemia (ALL) and diffuse large B cell lymphoma (DLBCL)
- Revised SPC: Curosurf (poractant alfa)
- Public Health England and Disney UK launch Change4Life Train Like A Jedi programme
- June BNF/BNFC eNewsletter
- Impact of Insulin and Metformin Versus Metformin Alone on β-Cell Function in Youth With Impaired Glucose Tolerance or Recently Diagnosed Type 2 Diabetes
- Perceptions of future health and cancer risk in adult survivors of childhood cancer: A report from the Childhood Cancer Survivor Study
- Metformin exposure in first trimester of pregnancy and risk of all or specific congenital anomalies: exploratory case-control study
- UK to review medical cannabis policy
- Maternal and infant outcomes associated with lithium use in pregnancy: an international collaborative meta-analysis of six cohort studies
- The respiratory syncytial virus vaccine landscape: lessons from the graveyard and promising candidates
- Idiopathic nephrotic syndrome in children
- Burosumab for treating X-linked hypophosphataemia in children and young people: Evaluation consultation
- Spiriva (tiotropium) Respimat licensed in UK for treatment of asthma in patients aged six years and above
- Treatment and secondary prophylaxis with ethanol lock therapy for central line-associated bloodstream infection in paediatric cancer: a randomised, double-blind, controlled trial
- Effectiveness and safety of long-term treatment with sulfonylureas in patients with neonatal diabetes due to KCNJ11 mutations: an international cohort study
- At-risk children with asthma (ARC): a systematic review
- European CHMP recommends approval of adalimumab biosimilars (Halimatoz, Hefiya and Hyrimoz)
- European CHMP recommends approval of nitisinone (Nityr) for treatment of hereditary tyrosinemia type 1
May 2018
- Nonpharmacologic Treatments for Attention-Deficit/Hyperactivity Disorder: A Systematic Review
- Association Between Vitamin D Supplementation During Pregnancy and Offspring Growth, Morbidity, and Mortality – A Systematic Review and Meta-analysis
- Mass chemoprophylaxis for control of outbreaks of meningococcal disease
- Adolescent affective symptoms and mortality
- Higher versus lower amino acid intake in parenteral nutrition for newborn infants
- Beta-blockers for prevention and treatment of retinopathy of prematurity in preterm infants
- Important considerations for interpreting biochemical tests in children
- US FDA accepts supplemental biologics license application for prophylactic and paediatric use of Coagadex® (Coagulation Factor X, Human) for treatment of hereditary factor X deficiency
- Antibiotics at the time of removal of central venous catheter to reduce morbidity and mortality in newborn infants
- Immunoglobulin for alloimmune hemolytic disease in neonates
- European Medicines Agency investigating new study suggesting increased risk of neural tube defects in infants born to women who took dolutegravir at conception
- Systemic corticosteroids for acute otitis media in children
- Developmental follow-up of children and young people born preterm – quality standard (QS169)
- Cystic fibrosis – quality standard (QS168)
- Guidelines for the use of hydroxycarbamide in children and adults with sickle cell disease
- The use of complementary and alternative medicines during breastfeeding: results from the Herbal supplements in Breastfeeding InvesTigation (HaBIT)
- US FDA approves oral brivaracetam for the treatment of partial-onset (focal) seizures in paediatric patients
- Chemotherapy-Induced Peripheral Neuropathy in Long-term Survivors of Childhood Cancer Clinical, Neurophysiological, Functional, and Patient-Reported Outcomes
- Prophylactic vitamin K for the prevention of vitamin K deficiency bleeding in preterm neonates
- FDA expands approval of fingolimod (Gilenya) to treat multiple sclerosis in paediatric patients
- Which weak opioids can be used during breastfeeding? Considering the evidence for codeine, dihydrocodeine, and tramadol
- Prevalence estimates and risk factors for early childhood wheeze across Europe: the EuroPrevall birth cohort
- Data from the US and UK cystic fibrosis registries support disease modification by CFTR modulation with ivacaftor
- Which oral antihistamines are safe to use whilst breastfeeding?
- Vaccines for preventing influenza in healthy children
- Melatonin for the management of sleep problems in children with neurodevelopmental disorders: a systematic review and meta-analysis
- NIHR Signal: Domperidone increases breast milk production in mothers of premature babies
- Can mothers breastfeed after a medical termination of pregnancy?
- Breastfeeding and lithium: is breast always best?
- Inhaled mannitol for cystic fibrosis
- Emollient bath additives for the treatment of childhood eczema (BATHE): multicentre pragmatic parallel group randomised controlled trial of clinical and cost effectiveness
- Early antiretroviral therapy in HIV-infected infants: can it lead to HIV remission?
- Effect of Atropine With Propofol vs Atropine With Atracurium and Sufentanil on Oxygen Desaturation in Neonates Requiring Nonemergency Intubation: A Randomized Clinical Trial
- Extended-release methylphenidate – An updated review of the pharmacokinetic profiles of available preparations
- Prostaglandin E1 for maintaining ductal patency in neonates with ductal-dependent cardiac lesions
April 2018
- European CHMP recommends approval of new paediatric indication for dasatinib (Sprycel)
- Maternal caffeine intake during pregnancy and childhood growth and overweight: results from a large Norwegian prospective observational cohort study
- Oral antiplatelet agents – are they safe in breastfeeding?
- Anti-vascular endothelial growth factor (VEGF) drugs for treatment of retinopathy of prematurity
- April 2018 BNF/BNF-C eNewsletter.
- Drug management for acute tonic-clonic convulsions including convulsive status epilepticus in children
- RMOC Recommendation: Standardising strengths of high risk, unlicensed oral liquids formulations for anti-TB medicines
- Ministers write letter over Orkambi (lumacaftor/ivacaftor) access
- Cardiopulmonary Resuscitation in Infants and Children With Cardiac Disease: A Scientific Statement From the American Heart Association
- Weighing the risks of valproate in women who could become pregnant
- Large differences in neonatal drug use between NICUs are common practice: time for consensus?
- NIHR Signal: Lorazepam confirmed as first-line treatment for stopping prolonged seizures in children
- Gabapentin and pregabalin—are they safe whilst breastfeeding?
- Which medicines require extra care when switching between liquid and tablet/capsule formulations?
- Medical and dietary interventions for preventing recurrent urinary stones in children
- Public Health England continues to urge parents to look out for the symptoms of scarlet fever following significant upsurge in cases
- Early erythropoiesis-stimulating agents in preterm or low birth weight infants
- Lung function trajectories from pre-school age to adulthood and their associations with early life factors: a retrospective analysis of three population-based birth cohort studies
- Altemia receives orphan drug designation from the European Medicines Agency for paediatric sickle cell disease
- Neonatal Abstinence Syndrome: Advances in Diagnosis and Treatment
- The routine immunisation schedule from Spring 2018
- Supplemental New Drug Application for paediatric use of perampanel submitted to US FDA
March 2018
- Be brave –
- March BNF/BNFC eNewsletter
- NIHR Signal: Self-care support for children with long-term conditions may reduce emergency costs
- European CHMP recommends extension of fosaprepitant indication to include paediatric patients
- Nilotinib (Tasigna®) approved in the US for treatment of paediatric patients with Philadelphia chromosome-positive chronic myeloid leukaemia in the chronic phase
- The Relationship Between Oseltamivir and Suicide in Pediatric Patients
- Methylphenidate for children and adolescents with autism spectrum disorder
- Causes of death among children aged 5–14 years in the WHO European Region: a systematic analysis for the Global Burden of Disease Study 2016
- British Society of Haematology Guideline: management of thrombotic and haemostatic issues in paediatric malignancy
- Enzyme replacement therapy for infantile-onset Pompe disease
- Risk Minimisation Material for use of tenofovir disoproxil in adults and adolescent children with chronic hepatitis B
- Attention deficit hyperactivity disorder – quality standard (QS39)
- Effect of a Pediatric Early Warning System on All-Cause Mortality in Hospitalized Pediatric Patients: The EPOCH Randomized Clinical Trial
- Chloral hydrate as a sedating agent for neurodiagnostic procedures in children
- Attention deficit hyperactivity disorder: diagnosis and management – updated guidance (NG87)
- The Changing Landscape of Pediatric Migraine Therapy: A Review
- Are we listening? A review of children and young people’s mental health services
- Association Between Estimated Cumulative Vaccine Antigen Exposure Through the First 23 Months of Life and Non–Vaccine-Targeted Infections From 24 Through 47 Months of Age
- Quintupling Inhaled Glucocorticoids to Prevent Childhood Asthma Exacerbations
- Should universal distribution of high dose vitamin A to children cease?
- ‘Pill School’ project launched to teach children how to swallow tablets
- Topiramate use early in pregnancy and the risk of oral clefts: A pregnancy cohort study
- Adverse effects of amphotericin B in children; a retrospective comparison of conventional and liposomal formulations
- Children’s toothache is becoming everybody’s business: where do parents go when their children have oral pain in London, England? A cross-sectional analysis
- Diet during pregnancy and infancy and risk of allergic or autoimmune disease: A systematic review and meta-analysis
February 2018
- FDA accepts New Drug Application for Stannsoporfin for severe neonatal jaundice
- February BNF/BNFC eNewsletter
- European CHMP recommends approval of glibenclamide (Amglidia) for the treatment of neonatal diabetes mellitus in newborns, infants and children
- Accuracy of intravenous and enteral preparations involving small volumes for paediatric use: a review
- Infant Hospitalizations and Mortality After Maternal Vaccination
- Discontinuities and disruptions in drug dosage guidelines for the paediatric population
- The social and economic impact of ADHD
- Maternal thyroid function and child educational attainment: prospective cohort study
- Implementing an oxygen weaning guideline for babies with chronic neonatal lung disease
- Association Between Prenatal Valproate Exposure and Performance on Standardized Language and Mathematics Tests in School-aged Children
- Oseltamivir or zanamivir – can mothers breastfeed after treatment for influenza?
- Prophylactic antibiotics for preventing pneumococcal infection in children with sickle cell disease
- Intravenous immunoglobulin for the treatment of childhood encephalitis
- Prophylactic intravenous calcium therapy for exchange blood transfusion in the newborn
- Inhaled versus systemic corticosteroids for the treatment of bronchopulmonary dysplasia in ventilated very low birth weight preterm
- Inhaled versus systemic corticosteroids for preventing bronchopulmonary dysplasia in ventilated very low birth weight preterm neonates
- Prenatal exposure to acetaminophen and children’s language development at 30 months
- Hypervigilance to a Gluten-Free Diet and Decreased Quality of Life in Teenagers and Adults with Celiac Disease
- NIHR Signal: Takeaways linked to increased cardiovascular risk factors and obesity in children
- Influenza vaccines for preventing acute otitis media in infants and children
- Reducing inappropriate antibiotic prescribing for children in primary care: a cluster randomised controlled trial of two interventions
- Late (> 7 days) systemic postnatal corticosteroids for prevention of bronchopulmonary dysplasia in preterm infants
- Early (< 8 days) systemic postnatal corticosteroids for prevention of bronchopulmonary dysplasia in preterm infants
- Phase II, Open-Label, Randomized, Multicenter Trial (HERBY) of Bevacizumab in Pediatric Patients With Newly Diagnosed High-Grade Glioma
- Effectiveness of a childhood obesity prevention programme delivered through schools, targeting 6 and 7 year olds: cluster randomised controlled trial (WAVES study)
- Vitamin A supplements for reducing mother‐to‐child HIV transmission
- Junior doctors’ communication with hospital pharmacists about prescribing: findings from a qualitative interview study
- Is the provision of paediatric oral liquid unlicensed medicines safe?
- Growth hormone therapy for people with thalassaemia
- Public Health England urges vigilance about spotting signs of scarlet fever
- High versus standard volume enteral feeds to promote growth in preterm or low birth weight infants
- Treatments for priapism in boys and men with sickle cell disease
- Tisagenlecleucel in Children and Young Adults with B-Cell Lymphoblastic Leukemia
January 2018
- Experts urge addition of folic acid to flour to halt “avoidable tragedy” of birth defects
- Transition from Child and Adolescent Mental Health Services to Adult Mental Health Services
- Vitamin K supplementation for cystic fibrosis
- Antibiotics for persistent cough or wheeze following acute bronchiolitis in children
- Tailored interventions based on sputum eosinophils versus clinical symptoms for asthma in children and adults
- Late (≥ 7 days) inhalation corticosteroids to reduce bronchopulmonary dysplasia in preterm infants
- Oncological management and obstetric and neonatal outcomes for women diagnosed with cancer during pregnancy: a 20-year international cohort study of 1170 patients
- Repaglinide versus insulin for newly diagnosed diabetes in patients with cystic fibrosis: a multicentre, open-label, randomised trial Antiepileptic drugs for chronic non‐cancer pain in children and adolescents
- Antidepressants for chronic non‐cancer pain in children and adolescents
- Slow advancement of enteral feed volumes to prevent necrotising enterocolitis in very low birth weight infants
- Interventions for preventing and managing advanced liver disease in cystic fibrosis
- Patient information leaflet – Group B Strep (GBS) in pregnancy and newborn babies
- State of Child Health: One Year On
- European Commission approves ipilimumab for the treatment of paediatric patients 12 years and older with unresectable or metastatic melanoma
- Association of Time to Treatment With Short-term Outcomes for Pediatric Patients With Refractory Convulsive Status Epilepticus
- Immunogenicity and safety of the multicomponent meningococcal B vaccine (4CMenB) in children and adolescents: a systematic review and meta-analysis
- Prophylactic levosimendan for the prevention of low cardiac output syndrome and mortality in paediatric patients undergoing surgery for congenital heart disease
- Sildenafil for pulmonary hypertension in neonates
- Paracetamol (acetaminophen) for chronic non‐cancer pain in children and adolescents
- Non‐steroidal anti‐inflammatory drugs (NSAIDs) for chronic non‐cancer pain in children and adolescents
- Fluid supplementation for neonatal unconjugated hyperbilirubinaemia
- US FDA accepts for review application for clobazam oral Soluble Film (OSF) for adjunctive treatment of seizures associated with Lennox-Gastaut syndrome (LGS) in patients aged 2 years and above
- European Medicines Agency publishes additional reports on decision-making for orphan medicines
- The UK Paediatric Familial Hypercholesterolaemia Register: Statin-related safety and 1-year growth data
- GPs’ experiences of diagnosing and managing childhood eczema: a qualitative study in primary care
- Safety and efficacy of tiotropium in children aged 1–5 years with persistent asthmatic symptoms: a randomised, double-blind, placebo-controlled trial
- MHRA advises parents and carers to inspect Buccolam oral syringes before use following the EMA safety alert
- Networked approach to implementing NG61 (End of life care for infants, children & young people)
- Oral prednisolone in preschool children with virus-associated wheeze: a prospective, randomised, double-blind, placebo-controlled trial
- Antibiotic prescribing quality for children in primary care: an observational study
- Defect with Buccolam (midazolam) oral syringes
- FDA approves paediatric license extension of Fluarix quadrivalent (influenza vaccine) for babies 6 months and older
- Pregnancy outcomes in women on metformin for diabetes or other indications among those seeking teratology information services
- Acid-Suppressive Drug Use During Pregnancy and the Risk of Childhood Asthma: A Meta-analysis
- Disease Course and Treatment Responses in Children With Relapsing Myelin Oligodendrocyte Glycoprotein Antibody–Associated Disease
- Nasogastric (NG) feeding tubes – recall due to risk of neonatal or paediatric patient choking on ENFIT connector cap
- Association of Maternal Use of Folic Acid and Multivitamin Supplements in the Periods Before and During Pregnancy With the Risk of Autism Spectrum Disorder in Offspring
- Marketing Authorisation Application submitted in EU for Epidiolex (cannabidiol) in the Treatment of Lennox-Gastaut Syndrome and Dravet Syndrome
- Admissions of inequality: emergency hospital use for children and young people
- Improving treatment of asthma attacks in children
- Sickle cell treatment endari receives positive opinion on paediatric investigation plan from European Medicines Agency
- Association of Folic Acid Supplementation During Pregnancy With the Risk of Autistic Traits in Children Exposed to Antiepileptic Drugs In Utero
December 2017
- December BNF/BNF-C eNewsletter
- Association of Broad- vs Narrow-Spectrum Antibiotics With Treatment Failure, Adverse Events, and Quality of Life in Children With Acute Respiratory Tract Infections
- Nasogastric (NG) feeding tubes – recall due to risk of neonatal or paediatric patient choking on ENFIT connector cap
- Fingolimod granted FDA breakthrough therapy designation for paediatric multiple sclerosis (MS)
- Statins for children with familial hypercholesterolemia
- European CHMP recommends approval of paediatric license extension of emtricitabine / tenofovir disoproxil (Truvada)
- Childhood and Adolescent Adversity and Cardiometabolic Outcomes: A Scientific Statement From the American Heart Association
- Opioids for cancer‐related pain in children and adolescents
- Mycophenolate: updated recommendations for contraception for men and women
- Developmental follow-up of children and young people born preterm: Quality standard consultation
- Cystic fibrosis: Quality standard consultation
- Oral dextrose gel to prevent hypoglycaemia in at‐risk neonates
- Non‐steroidal anti‐inflammatory drugs (NSAIDs) for cancer‐related pain in children and adolescents
- Medical Cannabinoids in Children and Adolescents: A Systematic Review
- Opioids for chronic non‐cancer pain in children and adolescents
- Eating disorders in children and young people
- Management for intussusception in children
- Transforming children and young people’s mental health provision: a green paper
- Combination antimicrobial susceptibility testing for acute exacerbations in chronic infection of Pseudomonas aeruginosa in cystic fibrosis
- Revised SPC: Cubicin (daptomycin) injection – paediatric extension
- Diagnostic Accuracy of Pediatric Teledermatology Using Parent-Submitted Photographs: A Randomized Clinical Trial
- Antibiotics for neonates born through meconium‐stained amniotic fluid
- Children and young people’s survey 2016
- Asthma: diagnosis, monitoring and chronic asthma management – guidance (NG80)
November 2017
- European Commission approves license extension for nilotinib to include first and second-line treatment of Philadelphia chromosome-positive chronic myeloid leukemia in the chronic phase (Ph+ CML-CP) in children
- Reduced-Intensity Delayed Intensification in Standard-Risk Pediatric Acute Lymphoblastic Leukemia Defined by Undetectable Minimal Residual Disease: Results of an International Randomized Trial (AIEOP-BFM ALL 2000)
- Undernutrition and severe acute malnutrition in children
- Cyanotic congenital heart disease following fertility treatments in the United States from 2011 to 2014
- Efficacy and Safety of HLD200, Delayed-Release and Extended-Release Methylphenidate, in Children with Attention-Deficit/Hyperactivity Disorder
- National Maternity and Perinatal Audit: Clinical report 2017
- European CHMP issues positive opinion for paediatric license extension of Nplate (romiplostim) for chronic immune (idiopathic) thrombocytopenic purpura
- European CHMP issues positive opinion for paediatric license extension of Genvoya (elvitegravir, cobicistat, emtricitabine, tenofovir alafenamide fumarate) for treatment of HIV
- Revised SPC: Emend (aprepitant) 125 mg powder for oral suspension
- Pharmacokinetic interactions and dosing rationale for antiepileptic drugs in adults and children
- Tezacaftor–Ivacaftor in Residual-Function Heterozygotes with Cystic Fibrosis
- Tezacaftor–Ivacaftor in Patients with Cystic Fibrosis Homozygous for Phe508del
- Adalimumab, etanercept and ustekinumab for treating plaque psoriasis in children and young people: systematic review and economic evaluation
- Increasing admissions to paediatric intensive care units in England and Wales: more than just rising a birth rate
- Atrial Fibrillation Burden in Young Patients with Congenital Heart Disease
- Interim guidelines for the public health management of scarlet fever outbreaks in schools, nurseries and other childcare settings October 2017
October 2017
- European approval for license extension for icatibant for the symptomatic treatment of acute attacks of hereditary angioedema in patients with C1-esterase-inhibitor deficiency
- CQC completes initial review of mental health services for children and young people
- Diagnosis and management of cystic fibrosis: summary of NICE guidance
- Strimvelis for treating severe combined immunodeficiency caused by adenosine deaminase deficiency: Appraisal Consultation Document
- Interventions to prevent global childhood overweight and obesity: a systematic review
- DTaP/IPV (Infanrix®-IPV or Repevax®): patient group direction (PGD) template
- Management of paediatric hernia
- Short and long term complications of in utero exposure to lamotrigine
- CHMP adopts positive opinion for licence extension for paeds aged > 3years for peg-interferon alpha-2a
- CHMP adopts positive opinion for licence extension in paeds 1-17 years for daptomycin
- Live attenuated influenza vaccine for children
- Effect of iodine supplementation in pregnant women on child neurodevelopment: a randomised, double-blind, placebo-controlled trial
- Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population-based measurement studies in 128·9 million children, adolescents, and adults
- Association of Insulin Pump Therapy vs Insulin Injection Therapy With Severe Hypoglycemia, Ketoacidosis, and Glycemic Control Among Children, Adolescents, and Young Adults With Type 1 Diabetes
- Revised SPC: Vimpat (Lacosamide) preparations – use in children from 4 years of age
- Ivacaftor (Kalydeco®)
- Immunosuppressive therapy for kidney transplant in children and young people – guidance (TA482)
- Cerebral palsy in children and young people
- ADHD in children and young people: prevalence, care pathways, and service provision
- European Medicines Agency (EMA) issues updated annex to excipient guidelines providing new safety advice for 15 excipients
- Dose correction of Ironorm (ferrous sulphate) drops in BNF for Children
- Child abuse and neglect – guidance (NG76)
- European Medicines Agency (EMA) publishes summary of its public hearing on valproate in pregnancy
- Appendix 1 Interactions: new interactions content for the BNF and BNF for Children has now been launched
- All schools can now purchase emergency adrenaline auto-injectors without prescription
- Antenatal nutritional supplementation and autism spectrum disorders in the Stockholm youth cohort: population based cohort study
- Sepsis in children: advice for health visitors and school nurses
- Conference report: Infants prescribed antacids for reflux have increased risk of bone fractures
September 2017
- September BNF/BNFC eNewsletter
- Faltering growth- recognition and management of faltering growth in children – guidance (NG75)
- Urinary tract infection in under 16s: diagnosis and management – guidance (CG54): update
- Therapeutic drug monitoring of voriconazole for treatment and prophylaxis of invasive fungal infection in children
- Updated Risk Minimisation Materials for Cinryze®▼ use in paediatric patients (C1 esterase inhibitor [human])
- EU approval for paediatric use of lacosamide (Vimpat)
- New product: Cystadrops (mercaptamine) 3.8mg/ml eye drops
- Renal toxicity and chemotherapy in children with cancer
- Childhood onset inflammatory bowel disease and risk of cancer: a Swedish nationwide cohort study 1964-2014
- Childhood Vaccination Coverage Statistics, England, 2016-17
- Access and waiting times in children and young people’s mental health services
- Health protection in schools and other childcare facilities
- Revised SPC: Varilrix (live attenuated varicella-zoster virus – Oka strain) vaccine
- Using emergency adrenaline auto-injectors in schools – guidance for schools
- Single-injection vaccine device still a long way off
- National Institute for Health Research Highlight: Childhood Eczema
- European CHMP recommends paediatric license extension of Stribild (elvitegravir / cobicistat / emtricitabine / tenofovir disoproxil)
- European CHMP recommends paediatric license extension of nilotinib (Tasigna)
- European CHMP recommends paediatric license extension of icatibant (Firazyr)
- End of life care for infants, children and young people (QS160)
- European Medicines Agency approves license extension for Humira (adalimumab) for anterior uveitis to include children
- FDA acknowledges qualified health claim linking early peanut introduction and reduced risk of developing peanut allergy
- Lancet Series on paediatric surgery
- Joint Scientific Advisory Committee on Nutrition (SACN)/ Committee on Toxicity (COT) Working Group statement on the timing of introduction of allergenic foods into the infant diet
- Flu immunisation for early years settings including child minders
- INN-108 (mesalamine and 4-aminophenylacetic acid [4-APAA]) granted Orphan Drug designation in the US for paediatric ulcerative colitis
- The cumulative burden of surviving childhood cancer: an initial report from the St Jude Lifetime Cohort Study (SJLIFE)
- Revised SPC: Decapeptyl SR 22.5mg (triptorelin pamoate) – new indication for central precocious puberty
- Supporting junior doctors in safe prescribing
- Tracleer (bosentan) 32mg tablet for oral suspension approved in US for treatment of paediatric patients with pulmonary arterial hypertension
- London asthma standards for children and young people: Driving consistency in outcomes for children and young people across the capital
- Attention deficit hyperactivity disorder: 1 diagnosis and management update draft for consultation
- Guanfacine for the treatment of attention deficit hyperactivity disorder (ADHD)
- European Commission approves paediatric license extension and paediatric formulation of cinacalcet (Mimpara)
- New Drug Application for dasotraline for attention deficit hyperactivity disorder (ADHD) submitted to the US FDA
- Efficacy and Safety of Selective Serotonin Reuptake Inhibitors, Serotonin-Norepinephrine Reuptake Inhibitors, and Placebo for Common Psychiatric Disorders Among Children and Adolescents: A Systematic Review and Meta-analysis
August 2017
- FDA approves benznidazole for paediatric Chagas disease
- Maternal SSRI discontinuation, use, psychiatric disorder and the risk of autism in children: a meta-analysis of cohort studies
- Type 2 diabetes in adolescents and young adults
- Biologics License Application seeking approval of burosumab for the treatment of X-Linked Hypophosphatemia submitted to the FDA
- Asthma action plans for healthcare professionals working with non-English speakers
- Association of Childhood Body Mass Index and Change in Body Mass Index With First Adult Ischemic Stroke
- The Royal College of GPs and the Royal College of Paediatrics and Child Health commit to five shared principles
- US FDA to re-evaluate prescription opioid medications to treat cough in children
- Government announces next stage of childhood obesity plan
- Inpatient versus outpatient parenteral antibiotic therapy at home for acute infections in children: a systematic review
- Adrenaline auto-injectors: updated advice after European review
- Measles immunity gaps and the progress towards elimination: a multi-country modelling analysis
- Acute Respiratory Distress Syndrome
- Growth hormone prescribing and initial BMI SDS: Increased biochemical adverse effects and costs in obese children without additional gain in height
- Hypersalivation – can hyoscine hydrobromide be used to treat it?
- Hypersalivation – can glycopyrronium be used to treat it?
- Fever in under 5s: assessment and initial management (CG160) – update
- Developmental follow-up of children and young people born preterm – guidance (NG72)
- US FDA grants “Orphan Drug” designation for PLX-200 for Late Infantile Neuronal Ceroid Lipofuscinosis (LINCL)
- The National Childhood Flu Immunisation Programme 2017/18: Information for healthcare practitioners
- Association between maternal vitamin D status in pregnancy and neurodevelopmental outcomes in childhood: results from the Avon Longitudinal Study of Parents and Children (ALSPAC)
- Does inhaled steroid therapy help emerging asthma in early childhood?
- Risk of neonatal drug withdrawal after intrauterine co-exposure to opioids and psychotropic medications: cohort study
- Royal College of Paediatrics and Child Health: Position Statement on breastfeeding in the UK
- NIHR Signal: Fluoride varnish every six months helps protect children’s permanent teeth from decay
- NIHR Signal: Prescribing regular drugs to prevent febrile convulsions risks more harm than benefit
- Asfotase alfa for treating paediatric-onset hypophosphatasia – guidance (HST6)
- European Commission approves license extension for ledipasvir/sofosbuvir (Harvoni) to include adolescents
- Epilim (sodium valproate) risk management materials: Letters to healthcare professionals, and poster warning of use of valproate products in girls/women
July 2017
- Improving the global diagnosis and management of asthma in children
- Clinical Trial of Fluid Infusion Rates for Pediatric Diabetic Ketoacidosis
- Inpatient provision for children and young people with mental health problems
- Strensiq (asfotase alfa) risk management materials: Self-injection guide and guide for parents/carers administering to infants
- Advances in the diagnosis of pneumonia in children
- FDA approves licence extension for ipilimumab to include children 12 years and older with unresectable or metastatic melanoma (MM)
- Incompatible intravenous drug combinations and respective physician and nurse knowledge: a study in routine paediatric intensive care
- The Montreux definition of neonatal ARDS: biological and clinical background behind the description of a new entity
- European Medicines Agency approves ciclosporin eye drops (Verkazia) for vernal keratoconjunctivitis (VKC) in children from four years of age and adolescents
- European Committee for Medicinal Products for Human Use (CHMP) adopts positive opinion for extension of license for sofosbuvir (Sovaldi) to include paediatric population
- European Committee for Medicinal Products for Human Use (CHMP) adopts positive opinion for extension of license for lacosamide (Vimpat) to include paediatric population
- European Committee for Medicinal Products for Human Use (CHMP) adopts positive opinion for extension of license for adalimumab (Humira) for uveitis
- Revised SPC: Infanrix hexa (Diphtheria/tetanus/pertussis/hepatitis B/poliomyelitis/Haemophilus influenzae type b), Powder and suspension for suspension for injection
- Number of children getting enough physical activity drops by 40%
- A telephone survey to determine the experiences of children and their parents/carers, following the initiation of a new medicine
- National Paediatric Diabetes Audit: Hospital Admissions and complications
- Stimulant medication to treat attention-deficit/hyperactivity disorder
- Blinatumomab (Blincyto) receives full approval in US as treatment for adults and children with relapsed or refractory B-cell precursor acute lymphoblastic leukaemia
- Orphan drug application for INN-108 submitted to FDA for treatment of ulcerative colitis in children
- Procalcitonin-guided decision making for duration of antibiotic therapy in neonates with suspected early-onset sepsis: a multicentre, randomised controlled trial (NeoPIns)
- Adalimumab, etanercept and ustekinumab for treating plaque psoriasis in children and young people – guidance (TA455)
- Clonidine for sedation and analgesia for neonates receiving mechanical ventilation
- Antiepileptic drugs for the treatment of infants with severe myoclonic epilepsy
- Immunisations for young people
- Childhood immunisation: quick guide for parents of premature babies (update)
- Neurocognitive Functioning of Children Treated for High-Risk B-Acute Lymphoblastic Leukemia Randomly Assigned to Different Methotrexate and Corticosteroid Treatment Strategies: A Report From the Children’s Oncology Group
- Immunisations at one year of age (for babies born on or after the 1 August 2017)
- Quarterly vaccination coverage statistics for children aged up to five years in the UK (COVER programme): January to March 2017
- Enuresis: practical guidelines for primary care
- Updated Educational Risk Minimisation Materials for Benepali® (etanercept biosimilar)
- Barriers to and facilitators of smoking cessation in pregnancy and following childbirth: literature review and qualitative study
- June BNF/BNFC eNewsletter
June 2017
- Withdrawal of the marketing authorisation application for levamisole (Elmisol) for paediatric nephrotic syndrome
- Paediatric Gliomas: Current Concepts on Diagnosis, Biology, and Clinical Management
- State of child health: The report in a glance
- Each Baby counts: 2015 Summary report
- Urinary tract infection in under 16s: DRAFT guideline update
- Guideline for the Management of Fever and Neutropenia in Children With Cancer and Hematopoietic Stem-Cell Transplantation Recipients: 2017 Update
- Flu vaccines for children
- Child and maternal health data and intelligence: a guide for health professionals
- Study results demonstrate minimal to no placental transfer of certolizumab (Cimzia®) from mother to infant during third trimester
- Effect of Low-Dose Ferrous Sulfate vs Iron Polysaccharide Complex on Hemoglobin Concentration in Young Children With Nutritional Iron-Deficiency Anemia: A Randomized Clinical Trial
- Burtomab receives US Breakthrough Therapy Designation for treatment of paediatric patients with relapsed or refractory metastatic neuroblastoma
- New product: Epistatus (midazolam) 10 mg Oromucosal Solution
- Identifying and managing neonatal hypoglycaemia in full term infants
- BSACI guideline for the diagnosis and management of peanut and tree nut allergy
- Quetiapine extended release versus aripiprazole in children and adolescents with first-episode psychosis: the multicentre, double-blind, randomised tolerability and efficacy of antipsychotics (TEA) trial
- Measles, mumps and rubella (MMR) vaccine information leaflet for new mums
- Prenatal antidepressant use and risk of attention-deficit/hyperactivity disorder in offspring: population based cohort study
- Diagnosis and management of inflammatory bowel disease in children
May 2017
- Vaccine update: issue 263, May 2017
- Arginine supplementation for prevention of necrotising enterocolitis in preterm infants
- Long-Term Risk of Subsequent Malignant Neoplasms After Treatment of Childhood Cancer in the DCOG LATER Study Cohort: Role of Chemotherapy
- Levetiracetam containing products 100 mg/mL oral solution presentations: Risk of medication errors associated with overdose
- European Committee for Orphan Medicinal Products (COMP) grants positive opinion for ibutamoren for the treatment of paediatric growth hormone deficiency
- Very strict blood sugar control in critically ill children provides no benefit
- Asthma education for school staff
- Stroke in Childhood: Clinical guideline for diagnosis, management and rehabilitation (2017)
- Cardiopulmonary Resuscitation in Adults and Children With Mechanical Circulatory Support: A Scientific Statement From the American Heart Association
- Enuresis: practical guidelines for primary care
- U.S. FDA accepts for review supplemental new drug application (sNDA) for eslicarbazepine acetate for partial-onset seizures in children aged 4 To 17 years
- Conference report: Study evaluating lurasidone in children and adolescents with bipolar depression meets primary endpoint
- Questions and answers on dexrazoxane (Cardioxane)
- European CHMP recommends paediatric license extension of travaprost (Izba) for ocular hypertension or paediatric glaucoma
- Identification and Management of Neonatal Hypoglycaemia in the Full Term Infant – A Framework for Practice
- Conference report: Early Antacid Exposure Increases Fracture Risk in Young Children
- May BNF/BNFC eNewsletter
- Topiramate monotherapy for juvenile myoclonic epilepsy
- NICE consults on draft quality standard on cerebral palsy in children
- Infant Feeding and Risk of Type 1 Diabetes in Two Large Scandinavian Birth Cohorts
- A multinational, drug utilization study to investigate the use of dexmedetomidine (Dexdor®) in clinical practice in the EU
- Epinephrine Concentrations in EpiPens After the Expiration Date
- Ongoing vomiting in an infant
- Draft clinical guideline on diagnosis and management of cystic fibrosis issued for consultation
- Buprenorphine for the Treatment of the Neonatal Abstinence Syndrome
- Prophylactic levosimendan for the prevention of low cardiac output syndrome and mortality in paediatric patients undergoing surgery for congenital heart disease
- Guideline for the Management of Fever and Neutropenia in Children With Cancer and Hematopoietic Stem-Cell Transplantation Recipients: 2017 Update .
- Pharmacological interventions for recurrent abdominal pain in childhood